Many people have been transformed after their experiences with psychedelics. There are biologically alternating conditions in meditation as well.
You can pull up the roots and look at the plant and see much but what about the plant? In the same way you can alter the biological functions of the brain but eventually, if not immediately, it starts effecting all those functions until many of the original abilities are gone. U can see this in many musicians who have used such synthetic and natural drugs and herbs. What was once great music now becomes mediocre.